Senescence-associated secreted proteins (SASP)
In the last years, I have focused on the secretome of senescent cells. It is evident that senescence process may greatly affect also the composition of mesenchymal stem cells (MSC) secretome through a shift from functional paracrine signalling to production of senescent-associated secreted factors that have potent autocrine and paracrine activities. Changes in secretome profiles of MSC may great impair their activities, which depends on the capability to secrete many factors, like cytokines and chemokines.
In this setting, we have decided to carry out a comparative analysis of MSC secretome from young and senescent cultures and evaluate if factors secreted from old MSC cultures may induce senescence or arrest proliferation, or promote cytotoxic effects in young cells.
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