name: Umberto surname: Galderisi

Telephone: 0815667585

e.mail: umberto.galderisi@unicampania.it

Nationality: ITALIAN

Studies: 

• 1987 Master degree in Biological Sciences, summa cum laude, University of Naples, Naples, Italy.
• 1992 PhD, Department of Genetics, General and Molecular Biology, University of Naples, Naples, Italy.

Present Position: 

• Professor of Molecular Biology at the School of Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
• Adjunct Professor, Sbarro Inst. for Cancer Research and Mol. Medicine, Temple Univ, Philadelphia, PA, USA.
• Visiting Scientist at Genkok (Genome and Stem Center) of Erciyes University, Kaiseri, Turkey

Main Work Experiences: 

• 1996 Researcher at "Museum National d'Histoire Naturelle" in Paris, France.
• 1997/1999 Researcher at CEINGE (Biotech and Molecular Biology Center), Napoli, Italy.
• 1998/1999 Visiting Researcher at Jefferson Medical College, Philadelphia, PA, USA.
• 2001 to present Adjunct Researcher and Professor at Sbarro Inst, Temple University, Philadelphia, USA.
• 2003 Visiting Researcher at Center for Gene Theraphy, Tulane Univ, New Orleans, LA, USA.
• 2006/2011 Visiting Scientist at Heinrich Pette Inst of Hamburg University, Germany.

Membership

• National Association of Italian Biologist.
• International Society for Cellular Therapy (ISCT).
• ECSA (European Cellular Senescence Association).
• Founder and President of Stem Cell Research Italy, scientific association of researchers involved in stem cell studies (www.stemcellitaly.it).

Member of the following Editorial Boards

World Journal of Stem Cells, World Journal of Experimental Medicine, Stem Cell Discovery, Stem Cell Review and Reports, ISRN Stem Cells, Cancer & Clinical Research Journal, Frontier in Stem Cell Treatment, Journal of Cardiology and Therapy, Archives of Cytology, Imaging Journal of Clinical and Medical Sciences, Austin Journal of Molecular and Cellular Biology, Journal of Cancer Metastasis and Treatment, Interdisciplinary Journal of Bone Marrow & Research (JBMR), Gerontology.

Main current research interests:

• Basic and applied researches on normal and cancer stem cells.
• Analysis of senescence processes that affect stem cell properties.
• Effect of low dose radiations on the biology of normal and cancer stem cells.
• Secretome effects of Mesenchymal stromal cells
• The role of the Rb family proteins in the senescence
• MUSE cells
• RETT Syndrome 

Selected Publications:

He is co-author of more than 170 articles (H-index 42, citations 6537 by Scopus)

1: Alessio N, Pipino C, Mandatori D, Di Tomo P, Ferone A, Marchiso M, Melone MAB, Peluso G, Pandolfi A, Galderisi U. Mesenchymal stromal cells from amniotic fluid are less prone to senescence compared to those obtained from bone marrow: An in vitro study. J Cell Physiol. 2018 Nov;233(11):8996-9006. doi: 10.1002/jcp.26845. PubMed PMID: 29904927.

2: Squillaro T, Galano G, De Rosa R, Peluso G, Galderisi U. Concise Review: The Effect of Low-Dose Ionizing Radiation on Stem Cell Biology: A Contribution to Radiation Risk. Stem Cells. 2018 Aug;36(8):1146-1153. doi: 10.1002/stem.2836. PubMed PMID: 29664142.

3: Alessio N, Capasso S, Ferone A, Di Bernardo G, Cipollaro M, Casale F, Peluso G, Giordano A, Galderisi U. Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence. Neoplasia. 2017 Oct;19(10):781-790. doi: 10.1016/j.neo.2017.06.005 PMID: 28865301; PubMed Central PMCID: PMC5577395.

4: Alessio N, Esposito G, Galano G, De Rosa R, Anello P, Peluso G, Tabocchini MA, Galderisi U. Irradiation of Mesenchymal Stromal Cells With Low and High Doses of Alpha Particles Induces Senescence and/or Apoptosis. J Cell Biochem. 2017 Sep;118(9):2993-3002. doi: 10.1002/jcb.25961. Epub 2017 May 3. PubMed PMID: 28252222.

5: Özcan S, Alessio N, Acar MB, Mert E, Omerli F, Peluso G, Galderisi U. Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses. Aging (Albany NY). 2016 Jul;8(7):1316-29. doi: 10.18632/aging.100971. PubMed PMID: 27288264; PubMed Central PMCID: PMC4993333.

6: Alessio N, Capasso S, Di Bernardo G, Cappabianca S, Casale F, Calarco A, Cipollaro M, Peluso G, Galderisi U. Mesenchymal stromal cells having inactivated RB1 survive following low irradiation and accumulate damaged DNA: Hints for side effects following radiotherapy. Cell Cycle. 2017 Feb;16(3):251-258. doi: 10.1080/15384101.2016.1175798. PubMed PMID: 27124644; PubMed Central PMCID: PMC5323029.

7: Capasso S, Alessio N, Squillaro T, Di Bernardo G, Melone MA, Cipollaro M, Peluso G, Galderisi U. Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells. Oncotarget. 2015 Nov 24;6(37):39457-68. doi:10.18632/oncotarget.6277. PubMed PMID: 26540573.

8: Alessio N, Del Gaudio S, Capasso S, Di Bernardo G, Cappabianca S, Cipollaro M, Peluso G, Galderisi U. Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process. Oncotarget. 2015 Apr 10;6(10):8155-66. PubMed PMID: 25544750; PubMed Central PMCID: PMC4480742.

9: Zanichelli F, Capasso S, Di Bernardo G, Cipollaro M, Pagnotta E, Cartenì M, Casale F, Iori R, Giordano A, Galderisi U. Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage. Apoptosis. 2012 Sep;17(9):964-74. doi: 10.1007/s10495-012-0740-3. PubMed PMID: 22684843.

10: Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A. Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells. Cell Death Dis. 2013 Nov 7;4:e911. doi: 10.1038/cddis.2013.445. PubMed PMID: 2420181.