name: Giovanni surname: Di Bernardo

Telephone: 0815665838

e.mail: gianni.dibernardo@unicampania.it

Nationality: ITALY

Educational and Training 

Studies: 

  • 1994 Master degree in Biological Sciences, summa cum laude, University of Naples, Naples, Italy.
  • 2003 PhD in "Progettazione ed Impiego di molecole di interesse Biotecnologico" (XV ciclo) at the School of Medicine, Dept. of Medicina Sperimentale, 2nd University of Naples.

Present Position: 

  • Associate professor of Molecular Biology at the School of Medicine, Dept. of Medicina Sperimentale, University of Campania "Luigi Vanvitelli", Naples, Italy.

Main Work Experiences: 

  • 1994 Post-degree practical training at the School of Medicine, Institute of Biochemistry of Macromolecules, 2nd University of Naples, Naples, Italy
  • 1995-1996 Post-doctoral fellowship, P.F. FATMA, National Research Council (C.N.R.), Rome, Italy.
  • 1997-1998 Post-doctoral fellowship P. F. Beni Culturali, National Research Council (C.N.R.), Rome, Italy.
  • 1999 Post-doctoral fellowship P. F. Beni Culturali, National Research Council (C.N.R.), Rome, Italy.
  • 1999-2002 Post-doctoral fellowship at Department of Experimental Medicine, Second University of Napoli, Italy.
  • 2000 Visiting Researcher at The Kuvin Centre for the study of infectious and tropical disease", Hebrew University, Hadassah Medical School, Jerusalem-Israel.
  • 2003-2004 Post-doctoral fellowship at Department of Experimental Medicine, Second University of Napoli, Italy.
  • 2004-2007 Post-doctoral fellowship at Department of Experimental Medicine, Second University of Napoli, Italy.

Membership

Member of the following Editorial Boards

Journal Cellular Physiology, Journal Cellular Biochemistry, Journal of Neurochemistry, Current Drug Targets, Molecular and Cellular Neuroscience, Neuroscience Letters, Gerontology, Stem Cells and Development, World Journal of Stem Cells, Vascular Medicine, BMC Medical Genomics, Cell Biology and Toxicology, Bone, Human Molecular Genetics, Journal of the National Cancer Institute, Transgenic Research, Cancer Biology & Therapy, Future Oncology, Regenerative Medicine, Journal of Experimental & Clinical Cancer Research, Cellular and Molecular Life Sciences, Nucleus.

Research interests:

Main current research interests:

  • Basic and applied researches on normal and cancer stem cells.

  • Effect of low dose radiations on the biology of normal and cancer stem cells.

  • Analysis of senescence processes that affect stem cell properties.


Selected Publications:

He is co-author of more than 75 articles (H-index 24, citations 1640 by Scopus)

Di Maio G, Alessio N, Peluso G, Perrotta S, Monda M, Di Bernardo G. Molecular and Physiological Effects of Browning Agents on White Adipocytes from Bone Marrow Mesenchymal Stromal Cells. Int J Mol Sci. 2022 Oct 12;23(20):12151. doi: 10.3390/ijms232012151. PMID: 36293005; PMCID: PMC9603155.

Aprile D, Alessio N, Squillaro T, Di Bernardo G, Peluso G, Galderisi U. Role of glycosphingolipid SSEA-3 and FGF2 in the stemness and lineage commitment of multilineage differentiating stress enduring (MUSE) cells. Cell Prolif. 2022 Oct 12:e13345. doi: 10.1111/cpr.13345. Epub ahead of print. PMID: 36225120.

Alessio N, Squillaro T, Lettiero I, Galano G, De Rosa R, Peluso G, Galderisi U, Di Bernardo G. Biomolecular Evaluation of Piceatannol's Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics? Int J Mol Sci. 2021 Oct 27;22(21):11619. doi: 10.3390/ijms222111619. PMID: 34769049; PMCID: PMC8583715.

Acar MB, Ayaz-Güner Ş, Gunaydin Z, Karakukcu M, Peluso G, Di Bernardo G, Özcan S, Galderisi U. Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells. Front Bioeng Biotechnol. 2021 Oct 5;9:730813. doi: 10.3389/fbioe.2021.730813. PMID: 34676202; PMCID: PMC8524175.

Galderisi U, Peluso G, Di Bernardo G. Clinical Trials Based on Mesenchymal Stromal Cells are Exponentially Increasing: Where are We in Recent Years? Stem Cell Rev Rep. 2022 Jan;18(1):23-36. doi: 10.1007/s12015-021-10231-w. Epub 2021 Aug 16. PMID: 34398443; PMCID: PMC8365566.

Alessio N, Stellavato A, Aprile D, Cimini D, Vassallo V, Di Bernardo G, Galderisi U, Schiraldi C. Timely Supplementation of Hydrogels Containing Sulfated or Unsulfated Chondroitin and Hyaluronic Acid Affects Mesenchymal Stromal Cells Commitment Toward Chondrogenic Differentiation. Front Cell Dev Biol. 2021 Apr 12;9:641529. doi: 10.3389/fcell.2021.641529. PMID: 33912558; PMCID: PMC8072340.

Aprile D, Alessio N, Demirsoy IH, Squillaro T, Peluso G, Di Bernardo G, Galderisi U. MUSE Stem Cells Can Be Isolated from Stromal Compartment of Mouse Bone Marrow, Adipose Tissue, and Ear Connective Tissue: A Comparative Study of Their In Vitro Properties. Cells. 2021 Mar 30;10(4):761. doi: 10.3390/cells10040761. PMID: 33808472; PMCID: PMC8065981.

Alessio N, Aprile D, Cappabianca S, Peluso G, Di Bernardo G, Galderisi U. Different Stages of Quiescence, Senescence, and Cell Stress Identified by Molecular Algorithm Based on the Expression of Ki67, RPS6, and Beta-Galactosidase Activity. Int J Mol Sci. 2021 Mar 18;22(6):3102. doi: 10.3390/ijms22063102. PMID: 33803589; PMCID: PMC8002939.

Acar MB, Aprile D, Ayaz-Guner S, Guner H, Tez C, Di Bernardo G, Peluso G, Ozcan S, Galderisi U. Why Do Muse Stem Cells Present an Enduring Stress Capacity? Hints from a Comparative Proteome Analysis. Int J Mol Sci. 2021 Feb 19;22(4):2064. doi: 10.3390/ijms22042064. PMID: 33669748; PMCID: PMC7922977.

Di Maio G, Alessio N, Demirsoy IH, Peluso G, Perrotta S, Monda M, Di Bernardo G. Evaluation of Browning Agents on the White Adipogenesis of Bone Marrow Mesenchymal Stromal Cells: A Contribution to Fighting Obesity. Cells. 2021 Feb 16;10(2):403. doi: 10.3390/cells10020403. PMID: 33669222; PMCID: PMC7919793.

Nicola Alessio, Tiziana Squillaro, Vincenzo Monda, Gianfranco Peluso, Marcellino Monda, Mariarosa AB Melone, Umberto Galderisi, Giovanni Di Bernardo Circulating factors present in the sera of naturally skinny people may influence cell commitment and adipocyte differentiation of mesenchymal stromal cells. World J Stem Cells 2019 March 26; 11(3): 0-0 DOI: 10.4252/wjsc.v11.i3.0000

Najahi H, Alessio N, Squillaro T, Conti GO, Ferrante M, Di Bernardo G, Galderisi U, Messaoudi I, Minucci S, Banni M. Environmental microplastics (EMPs) exposure alter the differentiation potential of mesenchymal stromal cells. Environ Res. 2022 Nov;214(Pt 4):114088. doi: 10.1016/j.envres.2022.114088. Epub 2022 Aug 13. PMID: 35973457.

Squillaro T, Alessio N, Di Bernardo G, Özcan S, Peluso G, Galderisi U. Stem Cells and DNA Repair Capacity: Muse Stem Cells Are Among the Best Performers. Adv Exp Med Biol. 2018;1103:103-113. doi: 10.1007/978-4-431-56847-6_5.

Alessio N, Stellavato A, Squillaro T, Del Gaudio S, Di Bernardo G, Peluso G, De Rosa M, Schiraldi C, Galderisi U. Hybrid complexes of high and low molecular weight hyaluronan delay in vitro replicative senescence of mesenchymal stromal cells: a pilot study for future therapeutic application. Aging (Albany NY). 2018 Jul 12;10(7):1575-1585. doi: 10.18632/aging.101493 

Alessio N, Squillaro T, Özcan S, Di Bernardo G, Venditti M, Melone M, Peluso G, Galderisi U. Stress and stem cells: adult Muse cells tolerate extensive genotoxic stimuli better than mesenchymal stromal cells. Oncotarget. 2018 Apr 10;9(27):19328-19341. doi: 10.18632/oncotarget.25039. eCollection 2018 Apr 10.

Alessio N, Riccitiello F, Squillaro T, Capasso S, Del Gaudio S, Di Bernardo G, Cipollaro M, Melone MAB, Peluso G, Galderisi U. Neural stem cells from a mouse model of Rett syndrome are prone to senescence, show reduced capacity to cope with genotoxic stress, and are impaired in the differentiation process. Exp Mol Med. 2018 Mar 22;50(3):1. doi: 10.1038/s12276-017-0005-x..

Alessio N, Capasso S, Di Bernardo G, Cappabianca S, Casale F, Calarco A, Cipollaro M, Peluso G, Galderisi U. Mesenchymal stromal cells having inactivated RB1 survive following low irradiation and accumulate damaged DNA: Hints for side effects following radiotherapy. Cell Cycle. 2017 Feb;16(3):251-258. doi:10.1080/15384101.2016.1175798.

Alessio N, Del Gaudio S, Capasso S, Di Bernardo G, Cappabianca S, Cipollaro M, Peluso G, Galderisi U. Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process. Oncotarget. 2015 Apr 10;6(10):8155-66.

Di Bernardo G, Messina G, Capasso S, Del Gaudio S, Cipollaro M, Peluso G, Casale F, Monda M, Galderisi U. Sera of overweight people promote in vitro adipocyte differentiation of bone marrow stromal cells. Stem Cell Res Ther. 2014 Jan 9;5(1):4. doi: 10.1186/scrt393. PubMed PMID: 24405848; 

Di Bernardo G, Alessio N, Dell'Aversana C, Casale F, Teti D, Cipollaro M, Altucci L, Galderisi U. Impact of histone deacetylase inhibitors SAHA and MS-275 on DNA repair pathways in human mesenchymal stem cells. J Cell Physiol. 2010 Nov;225(2):537-44. doi: 10.1002/jcp.22236.

Di Bernardo G, Galderisi U, Fiorito C, Squillaro T, Cito L, Cipollaro M, Giordano A, Napoli C. Dual role of parathyroid hormone in endothelial progenitor cells and marrow stromal mesenchymal stem cells. J Cell Physiol. 2010 Feb;222(2):474-80. doi: 10.1002/jcp.21976.


© 2019 Galderisi-lab,  Via L. De Crecchio 7, 80138 Napoli
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