name: Claudia surname: Moriello

Telephone: 0815667663

e.mail: claudia.moriello@unicampania.it

Nationality: ITALY

Educational and Training

Studies:

2021 Master Degree in Biology, summa cum laude with academic mention, University of Naples "Federico II", Italy.
2019 Bachelor Degree in General and Applied Biology, summa cum laude with academic mention, University of Naples "Federico II", Italy.

Present Position:

PhD student in Clinical and Experimental Medical Sciences XXXIX cycle - PON RI, University of Campania "Luigi Vanvitelli", Italy.

Main Work Experiences:

- 2023 fellowship CNR - Institute of Biomolecular Chemistry (CNR-ICB) – Pozzuoli (NA).
- 2022 traineeship CNR - Institute of Biomolecular Chemistry (CNR-ICB) – Pozzuoli (NA).
- 2021 Internship Molecular Biology Lab, Department of Biology, University of Naples "Federico II".

Skills:

RNA and DNA extraction, DNA and RNA gel electrophoresis, PCR, Real Time PCR. Cell Culture. Immunocytochemistry. Protein extraction and purification, SDS-PAGE, Western blotting. Electrophoretic Mobility Shift Assay (EMSA). Plasmidic DNA extraction and purification. Lipids extraction and purification. Mass spectometry.

Computer skills: PubMed, Quantity One (BioRad), IM1000 (Leica), NanoDrop 3.0.0, NanoDrop 1000 V 3.2.1, GelDoc EZ Imager (BioRad). Office suite.

Research interests:

Main current research interests:

Analysis of senescence processes that affect stem cell properties.

Selected Publications:

She is co-author of

Serino E, Iannotti FA, Al-Hmadi HB, Caprioglio D, Moriello C, Masi F, Hammami S, Appendino G, Vitale RM, Taglialatela-Scafati O. PPARα/γ-Targeting Amorfrutin Phytocannabinoids from Aerial Parts of Glycyrrhiza foetida. J Nat Prod. 2023 Nov 24;86(11):2435-2447. doi: 10.1021/acs.jnatprod.3c00509. Epub 2023 Nov 8. PMID: 37940359.
Kalkan H, Panza E, Pagano E, Ercolano G, Moriello C, Piscitelli F, Sztretye M, Capasso R, Di Marzo V, Iannotti FA. Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin. Cell Death Dis. 2023 Aug 23;14(8):544. doi: 10.1038/s41419-023-06080-9. PMID: 37612317; PMCID: PMC10447569.
Kalkan H, Pagano E, Paris D, Panza E, Cuozzo M, Moriello C, Piscitelli F, Abolghasemi A, Gazzerro E, Silvestri C, Capasso R, Motta A, Russo R, Di Marzo V, Iannotti FA. Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy. EMBO Mol Med. 2023 Mar 8;15(3):e16225. doi: 10.15252/emmm.202216225. Epub 2023 Jan 3. PMID: 36594243; PMCID: PMC9994484.
Lauritano A, Cipollone I, Verde R, Kalkan H, Moriello C, Iannotti FA, Di Marzo V, Piscitelli F. The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity. Front Aging Neurosci. 2022 Oct 14;14:926634. doi: 10.3389/fnagi.2022.926634. PMID: 36313013; PMCID: PMC9614236
Moriello C, Costabile M, Spinelli M, Amoresano A, Palumbo G, Febbraio F, Piscopo M. Altered Expression of Protamine-like and Their DNA Binding Induced by Cr(VI): A Possible Risk to Spermatogenesis? Biomolecules. 2022 May 14;12(5):700. doi: 10.3390/biom12050700. PMID: 35625627; PMCID: PMC9138527.
Lettieri G, Marra F, Moriello C, Prisco M, Notari T, Trifuoggi M, Giarra A, Bosco L, Montano L, Piscopo M. Molecular Alterations in Spermatozoa of a Family Case Living in the Land of Fires. A First Look at Possible Transgenerational Effects of Pollutants. Int J Mol Sci. 2020 Sep 13;21(18):E6710. Doi: 10.3390/ijms21186710. PMID: 32933216.